Answer:
Amyotrophic Lateral Sclerosis
Findings:
Bilateral symmetric hyperintensities along the expected course of corticospinal tract extending from corona radiata to brainstem on FLAIR sequence.
Discussion:
There is selective degeneration of somatic motor neurons of brain stem and spinal cord (lower motor neurons, LMN),large pyramidal neurons of motor cortex (upper motorneurons, UMN) and eventual loss of corticospinal tract (CST) fibers. Differential diagnosis : 1. Wallerian degeneration – bilateral hyperintensities along corticospinal tracts with proximal volume loss secondary to infarct 2. Hypertrophic olivary degeneration - Secondary degeneration of inferior olivary nucleus (ION), usually caused by primary lesions in dento-rubro-olivary pathway
Contributed By: DrAnbumalar,PG-Y3, Assistant Professor Dr. Chezhian MD, Prof. Babu Peter MD, DNB, B.I.R
Amyotrophic Lateral Sclerosis
Findings:
Bilateral symmetric hyperintensities along the expected course of corticospinal tract extending from corona radiata to brainstem on FLAIR sequence.
Discussion:
There is selective degeneration of somatic motor neurons of brain stem and spinal cord (lower motor neurons, LMN),large pyramidal neurons of motor cortex (upper motorneurons, UMN) and eventual loss of corticospinal tract (CST) fibers. Differential diagnosis : 1. Wallerian degeneration – bilateral hyperintensities along corticospinal tracts with proximal volume loss secondary to infarct 2. Hypertrophic olivary degeneration - Secondary degeneration of inferior olivary nucleus (ION), usually caused by primary lesions in dento-rubro-olivary pathway
Contributed By: DrAnbumalar,PG-Y3, Assistant Professor Dr. Chezhian MD, Prof. Babu Peter MD, DNB, B.I.R