Case Of the Week (COW) 22 June 2014
Answer:
Progressive supranuclear palsy.
Findings:
Atrophy & abnormal T2 hyperintensity in the tegmentum. Narrowing of the SN - MICKEY MOUSE SIGN. Characteristic alteration in the normal convex profile of superior surface of mid brain - HUMMING BIRD SIGN.
Discussion:
Progressive supranuclear palsy (PSP) is a neurodegenerative disease that results in severe disability. It is characterized by supranuclear vertical gaze palsy, pseudobulbar palsy, dystonic rigidity of the neck and upper extremities, and frequent falls . The main neuropathologic characteristics of PSP are neuronal degeneration and loss in the tegmentum of the midbrain, atrophy of the substantia nigra (SN), and changes in the red nucleus and globus pallidus. Atrophy & abnormal T2 hyperintensity in the tegmentum. Narrowing of the SN. Characteristic alteration in the normal convex profile of superior surface of midbrain.
Contributed By:
Dr.Balaji Ayyamperumal
Thanjavur Medical College
Answer:
Progressive supranuclear palsy.
Findings:
Atrophy & abnormal T2 hyperintensity in the tegmentum. Narrowing of the SN - MICKEY MOUSE SIGN. Characteristic alteration in the normal convex profile of superior surface of mid brain - HUMMING BIRD SIGN.
Discussion:
Progressive supranuclear palsy (PSP) is a neurodegenerative disease that results in severe disability. It is characterized by supranuclear vertical gaze palsy, pseudobulbar palsy, dystonic rigidity of the neck and upper extremities, and frequent falls . The main neuropathologic characteristics of PSP are neuronal degeneration and loss in the tegmentum of the midbrain, atrophy of the substantia nigra (SN), and changes in the red nucleus and globus pallidus. Atrophy & abnormal T2 hyperintensity in the tegmentum. Narrowing of the SN. Characteristic alteration in the normal convex profile of superior surface of midbrain.
Contributed By:
Dr.Balaji Ayyamperumal
Thanjavur Medical College